Pet slikanje in kvantitativna analiza slik pri demencah

Demenca predstavlja široko kategorijo možganskih bolezni, za katere je značilen upad kognitivnih sposobnosti kot so spomin, mišljenje ali orientacija. Diagnozo demence opravimo z uporabo kognitivnih testov in slikanja možganov s pozitronsko emisijsko tomografijo (PET). Pri PET se pri slikanju uporabi biomarker, ki je preprosto merljiv fiziološki parameter, pomemben za kliničen opis bolezenskega stanja. Najprimernejši biomarker pri boleznih, kjer je spremenjena aktivnost možganov, je radiofarmak 18 F - fluordeoksiglukoze (FDG). Analiza PET slik se opravi s pomočjo dveh metod: statistična parametrična kartografija (angl. Statistical parametric mapping, SPM) in Skaliran subprofilni model osnovan na analizi glavnih komponent (angl. Scaled Subprofile Model/Principal components analysis, SSM/PCA).

Pet imaging and quantitative image analysis in dementia

Dementia is a broad category of brain diseases characterized by decreased cognitive abilities, such as memory, thinking or orientation. Diagnosis of dementia is made by using cognitive tests and brain imaging by positron emission tomography (PET). For PET, a biomarker is used in imaging, which is a simply measurable physiological parameter relevant to the clinical description of the disease state. The most suitable biomarker for different diseases where metabolic brain activity is altered is radiotracer 18F – fludeoxyglucose. Analysis of PET images is done by two different methods - Statistical parametric mapping or SPM, and Scaled subprofile model/Principal component analysis or SSM/PCA.